- asheesh@cusb.ac.in
- ashomics@gmail.com
- +91-9414478655
Specialization :
Data mining, Database and Server Development, Evolutionary Structure Analysis
Experience : 16 years
(Teaching / Research) :
Dr. Asheesh Shanker received postdoctoral training at University of Lausanne, Switzerland and is actively involved in bioinformatics teaching/research since 2004. He published several research papers in peer-reviewed journals of national & international repute and also authored/co-authored 4 books.
My group works on computational data mining, development of computational pipeline for biological data analysis and database development. Apart from this, I start exploring the role of evolution in drug resistance, its effect on protein structure, and adaptability of a pathogen against its host.
- Publications :
- Priya P, Shanker A (2021) Coevolutionary forces shaping the fitness of SARS-CoV-2 spike glycoprotein against human receptor ACE2. Infection, Genetics and Evolution 87: 104646
- Jayaswal PK, Shanker A, Singh NK (2020) Genome wide annotation and characterization of young, intact long terminal repeat retrotransposons (In-LTR-RTs) of seven legume species. Genetica 148: 253-268.
- Kumar S, Kumari S, Shanker A (2020) In silico mining of simple sequence repeats in mitochondrial genomes of genus Orthotrichum. Journal of Scientific Research 64: 179-182.
- Kumar S, Shanker A (2020) Length variation of chloroplast simple sequence repeats in the genus Eucalyptus L’Hér. Plant Science Today 7(3): 353-359
- Jayaswal PK, Shanker A, Singh NK (2020) Genome-wide comparative and evolutionary analysis of transposable elements in eight different legume plants Indian Journal of Agricultural Sciences 90: 1025-1031.
- Kumar S, Shanker A (2020) In silico comparative analysis of simple sequence repeats in chloroplast genomes of genus Nymphaea. Journal of Scientific Research 64: 186-192.
- Anand K, Kumar S, Alam A, Shanker A (2019) Mining of microsatellites in mitochondrial genomes of order Hypnales (Bryopsida) Plant Science Today;6(sp1): 635-638
- Jayaswal PK, Shanker A, Singh NK (2019) Phylogeny of actin and tubulin gene homologs in diverse eukaryotic species. Indian J Genet 79: 284-291 DOI:10.31742/IJGPB.79S.1.20.
- Vats S, Shanker A (2019) Groups of coevolving positions provide drug resistance to Mycobacterium tuberculosis: a study using targets of first-line antituberculosis drugs. International journal of antimicrobial agents 53: 197-202
- Singh AK, Yadav S, Sharma K, Firdaus Z, Aditi P, Neogi K, Bansal M, Gupta MK, Shanker A, Singh RK, Prakash P (2018) Quantum Curcumin mediated inhibition of gingipains and mixed-biofilm of Porphyromonas gingivalis causing chronic periodontitis. RSC Advances 8: 40426- 445
- Kumar S, Shanker A (2018) Common, unique, and polymorphic simple sequence repeats in chloroplast genomes of genus Arabidopsis. Vegetos 31 (Special): 125-131
- 12. Goyal S, Jamal S, Shanker A, Grover A (2018) Structural basis for drug resistance mechanisms against anaplastic lymphoma kinase. Journal of Cellular Biochemistry 120: 768-777
- Rawat N, Shanker A, Joshi GK (2018) Bioinformatics analysis of a novel Glutaredoxin gene segment from a hot spring metagenomic DNA library. Meta Gene 18: 107-111
- Shukla N, Kuntal H, Shanker A, Sharma SN (2018) Mining and analysis of simple sequence repeats in the chloroplast genomes of genus Vigna. Biotechnology Research and Innovation 2: 9-18
- Shukla N, Kuntal H, Shanker A, Sharma SN (2018) Hydro-priming methods for initiation of metabolic process and synchronization of germination in mung bean (Vigna radiata L.) seeds. Journal of Crop Science and Biotechnology 21: 137-146
- Jamal S, Goyal S, Shanker A, Grover A (2017) Predicting neurological adverse drug reactions based on biological, chemical and phenotypic properties of drugs using machine learning models. Nature Scientific Reports 2017; DOI: 10.1038/s41598-017-00908-z
- Goyal S, Jamal S, Shanker A, Grover A (2017) Structural basis for drug resistance mechanisms against EGFR. Current Topics in Medicinal Chemistry 17: 1-13
- Jamal S, Goyal S, Shanker A, Grover A (2017) Machine learning and molecular dynamics based insights into mode of actions of insulin degrading enzyme modulators. Combinatorial Chemistry and High Throughput Screening 20: 1-13
- Shanker A (2016) Structural Analysis of Form I Ribulose-1, 5-Bisphosphate Carboxylase/Oxygenase BAOJ Bioinfo 1: 1
- Srivastava D, Shanker A (2016) Identification of simple sequence repeats in chloroplast genomes of Magnoliids through bioinformatics approach. Interdisciplinary Sciences: Computational Life Sciences 8: 327-336 DOI 10.1007/s12539-015-0129-4
- Jamal S, Goyal S, Shanker A, Grover A (2016) Computational screening and exploration of disease-associated genes in Alzheimer’s disease. Journal of Cellular Biochemistry 9999: 1-9
- Jamal S, Goyal S, Shanker A, Grover A (2016) Integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes. BMC Genomics 17: 807
- Shanker A (2016) Detection of simple sequence repeats in the chloroplast genome of Tetraphis pellucida Hedw. Plant Science Today 3: 207-210
- Kabra R, Kapil A, Attarwala K, Rai PK, Shanker A (2016) Identification of common, unique and polymorphic microsatellites among 73 cyanobacterial genomes. World J Microbiol Biotechnol 32: 71
- Singh A, Kaushik R, Mishra A, Shanker A, Jayaram B (2015) ProTSAV: A protein tertiary structure analysis and validation server. BBA Proteins and Proteomics 1864: 11-19
- Shanker A (2015) An update on sequenced chloroplast genomes of Bryophytes. Plant Science Today 2: 172-174
- Srivastava D, Shanker A (2015) In silico mining and analysis of simple sequence repeats in chloroplast genomes of order Rosales. Research Journal of Bioinformatics 2: 1-9
- Goyal S, Jamal S, Shanker A, Grover A (2015) Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships. BMC Genomics 16(Suppl 5):S8
- Jamal S, Goyal S, Shanker A, Grover A (2015) Checking the STEP-associated trafficking and internalization of glutamate receptors for reduced cognitive deficits: A machine learning approach-based cheminformatics study and its application for drug repurposing. PlosOne 10: e0129370
- Kapil A, Rai PK, Shanker A (2014) ChloroSSRdb: a repository of perfect and imperfect chloroplastic simple sequence repeats (cpSSRs) of green plants. Database DOI 10.1093/database/bau107 [IF: 2.627]
- Jugran J, Joshi GK, Bhatt JP, Shanker A (2016) Production and partial characterization of extracellular protease from Bacillus sp. GJP2 isolated from a hot spring. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 86: 171. DOI 10.1007/s40011-014-0434-4
- Shanker A (2014) Simple sequence repeats mining using computational approach in chloroplast genome of Marchantia polymorpha. Arctoa 23: 145-149
- Shanker A (2014) Computational mining of microsatellites in the chloroplast genome of Ptilidium pulcherrimum, a liverwort. International Journal of Environment 3: 50-58
- Kumar M, Kapil A, Shanker A (2014) MitoSatPlant: Mitochondrial microsatellites database of viridiplantae. Mitochondrion 19: 334-337. http://dx.doi.org/10.1016/j.mito.2014.02.002
- Shanker A, Sharma V (2012) Efficacy of maximum likelihood method and longer sequences in phylogenetic analysis. Res J Biotech 7: 114-118
- Shanker A (2012) Genome research in the cloud. OMICS A Journal of Integrative Biology 16: 422-428
- Shanker A, Sharma V, Daniell H (2011) Phylogenomic evidence of bryophytes’ monophyly using complete and incomplete data sets from chloroplast proteomes. JPBB 20: 288-292
- 38. Shanker A, Sharma V, Daniell H (2009) A novel index to identify unbiased conservation between proteomes. IJIB 7: 32-38
- Shanker A, Sharma V (2009) Annotation Jargon- It’s not too late to correct it. Current Science 97: 983-984
- Shanker A, Bhargava A, Bajpai R, Singh S, Srivastava S, Sharma V (2007) Bioinformatically mined simple sequence repeats in UniGenes of Citrus sinensis. Scientia Horticulturae 113: 353-361
- Shanker A, Singh A, Sharma V (2007) In silico mining in expressed sequences of Neurospora crassa for identification and abundance of microsatellites. Microbiological Research 162: 250-256
- Shanker A, Tripathi D, Khandelwal G, Sharma G, Agrawal S, Singh A, Sharma V (2006) Data Mining and Database Development for Simple Sequence Repeats of Takifugu rubripes (Japanese Pufferfish) Biochem Cell Arch 6: 1-12
- Patents : Nil
- Book :
- Shanker A (2018) Bioinformatics: Sequences, Structures, Phylogeny. Springer Nature Singapore Pte Ltd, p. 402 (ISBN 978-981-13-1561-9)
- Shanker A (2015) The programming language “Perl” for Biologists: Solutions for Beginners. GRIN Verlag GmbH, Germany, p. 188 (ISBN 978-3-656-90770-1)
- Shanker A, Sharma V (2012) Evolutionary analysis of plants using chloroplast proteome sequences. LAP Germany, p. 152 (ISBN 978-3-8473-7563-0)
- Sharma V, Munjal A, Shanker A (2008; 2016 IInd Edition) A Text Book of Bioinformatics. Rastogi Publications, Meerut, India, p. 260 (ISBN 978-81-7133-917-4); IInd Edition p. 350 (ISBN 978-93-5078-142-5)
- Publications :
- Singh A.Ka. Bhargava Aa., Gaur Rb., (2012) Role of Bioinformatics in Microbial study “by in book titled “Microbial Application. (Eds. Gaur R., Malhotra S. and Pandey R.R.) I.K. International Publication, New Delhi. ISBN: 9789381141014
- Bhargava Aa., Singh A.Ka., Gupta V.Kb. and Gaur R.*, (2012) “Microbes for Heavy Metal Remediation”, in book titled Biotechnology of Microbial Enzymes (Eds. Gaur R., Malhotra S. and Pandey R.R.) I.K. International Publication, New Delhi. ISBN: 9789381141014
- Singh A.K.,Gupta V.K.,.(2012) “Biological Databases for Microbial Pathways and Enzymes for pathogenesis” in Book tilted Biotechnology of Microbial Enzymes (Eds. Vijai Kumar Gupta and Manimaran Ayyachamy (National University of Ireland, Galway, Ireland), Nova. International Publ, New Delhi. ISBN: 978-1-62100-197-3.
- Singh A.K., Bhargava A., Kaur G., Sharma A., Misra K. (2012)Bioinformatics tools and resources for cancer diagnosis and drug development. In book titled “Horizons in cancer research” 2012,vol 51 Publishers Nova International USA.
- Singh A.K., Misra K. “Next Generation Sequencing developments in cancer research by Bioinformatics approaches in book Horizons in cancer research”, Publishers Nova International USA. 2015, ISBN: 978-1-63482-627-3.
- Singh A.K. (2017)Advances in Computer Aided drug designing in book “Biotechnology Recent trends and emerging dimension”, Ed. Atul Bhargava and S. Srivastava Publisher Taylor and Francis , 2017CRC press. ISBN: 9781138561083.
- Halder A.a, Yadav K.b , Katara P. C, Singh A.K. * 2020 “Bioinformatics resources for the prediction of cancer prognosis and its recurrence, in book “Recent Trends in computational Omics Concept and Methodology, Ed. Pramod Katara, 2020. Nova Science Publisher, USA.
- Agnik Haldar A., Singh A.K., (2021) Next-Generation Sequence Analysis for Clinical Applications in Book Titled “Translational Bioinformatics Applications in Healthcare” Ed. Khalid Raza, Nilanjan Dey, pp 23-40, CRC Press. ISBN 9780367705701.
- Patent :
- Books chapters :
- Kumar A and Arya PK (2020). ‘Database Resources for Drug Discovery’ in Singh DB (Editor) Computer-Aided Drug Design Springer Singapore. ISBN 978-981-15-6814-5 ISBN 978-981-15-6815-2 (eBook)
- Kumar A and Arya PK (2020). ‘Database Resources for Computational Omics’ in Katara P (Editor) Recent Trends in ‘Computational Omics: Concepts and Methodology’ NOVA Science Publishers, Inc., USA. ISBN: 978-1-53617-941-5
- Kumar A and Arya PK (2019). ‘Database resources for cyanobacterial Research’, in Singh PK, Kumar A, Singh VK and Shrivastava AK (ed.) Advances in Cyanobacterial Biology. Elsevier, Academic Press, USA. Paperback ISBN: 9780128193112, eBook ISBN: 9780128193129
- Kumar Anil (2019). ‘Introduction to biological databases’, in Jha, A.K. and Kumar U. (ed.) Recent Advances in Chemical Sciences and Biotechnology. New Delhi Publishers, New Delhi, pp. 25-51. ISBN: 978-93-85503-63-4
- Awards :
Indo Swiss Joint Research Programme (ISJRP) fellowship availed at University of Lausanne, Switzerland (2010). - Projects :
Comparison of chloroplast proteomes of bryophytes and pteridophytes to identify orthologous proteins and transition link between both lineages, UGC
Establishment of a server to compare small genomes/proteomes and generate concatenated gene/protein sequences dataset to be used in phylogenetic tree reconstruction, UGC
Established under the Central Universities Act, 2009 (Section 25 of 2009) as Central University of Bihar (CUB) and the name since changed by the Central Universities (Amendment) Act, 2014 to Central University of South Bihar (CUSB) is an institution of higher learning in the state of Bihar.
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EMAIL : info@cusb.com
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